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Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 185-190 doi: 10.15302/J-FASE-2014035

Abstract: DNA damage is one of the most common threats to meiotic cells.Here, we reviewed exogenous factors which could induce DNA damage.Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic developmentComplex DNA damage, double-strand breaks, represents a more difficult repair process and involves variousUnderstanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for

Keywords： DNA damage     double-strand breaks (DSBs)     oocyte     embryo    

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Mechanisms and impacts of chromosomal translocations in cancers

Jing H. Wang

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 263-274 doi: 10.1007/s11684-012-0215-5

Abstract: In particular, the contribution of frequency of DNA double strand breaks and spatial proximity of translocating

Keywords： DNA double strand breaks     chromosomal translocations     genomic instability     spatial proximity     carcinogenesis    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: DNA double-strand break (DSB) is generally regarded as the most lethal of all DNA lesions after radiationKu80, DNA-PK catalytic subunit (DNA-PKcs) and ataxia telangiectasia mutated (ATM) proteins are majoracquired by clone formation assay, and western blot was applied to detect the expressions of Ku80, DNA-PKcsdifferent in eight tumor cell lines and there was a positive correlativity between the expression of DNA-PKcsThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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Microbial community structure in different wastewater treatment processes characterized by single-strand

ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1,   Pages 116-121 doi: 10.1007/s11783-008-0018-8

Abstract: treatment pro cesses were studied by a culture-independent genetic fingerprinting technique single-strand

Keywords： technique single-strand     proportion     bioreactor     community diversity     fingerprinting technique    

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Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System Article

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Engineering 2023, Volume 29, Issue 10,   Pages 130-136 doi: 10.1016/j.eng.2022.05.023

Abstract:

DNA molecules are green materials with great potential for high-density and long-term data storageHowever, the current data-writing process of DNA data storage via DNA synthesis suffers from high costsHere, we developed a DNA movable-type storage system that can utilize DNA fragments pre-produced by cellIn this system, these pre-generated DNA fragments, referred to herein as "DNA movable types,"the costly and environmentally hazardous process of de novo DNA synthesis.

Keywords： 合成生物学     DNA信息存储     DNA活字存储系统     经济性DNA数据存储    

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Secondary transfer length and residual prestress of fractured strand in post-tensioned concrete beams

Lizhao DAI; Wengang XU; Lei WANG; Shanchang YI; Wen CHEN

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 3,   Pages 388-400 doi: 10.1007/s11709-022-0809-1

Abstract: is developed and used to predict the secondary transfer length and residual prestress of fractured strandResults shows that the fractured strand can be re-anchored in concrete through the secondary anchorage, and the secondary transfer length of fractured strand with the diameter of 15.2 mm is 1133 mm.The residual prestress of fractured strand increases gradually in the secondary transfer length, andWhen the fractured strand is fully anchored in concrete, a minor prestress loss will appear, and the

Keywords： post-tensioned concrete beams     strand fracture     secondary transfer length     residual prestress    

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The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 156-164 doi: 10.1007/s11684-012-0197-3

Abstract:

Single-strand break repair protein poly(ADP-ribose) polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNA damage responseThe present review will focus on recent progress on the role of PARP1 in the DNA damage response andresistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA

Keywords： PARP1     synthetic lethality     PARP inhibitor     DNA repair     cancer     NHEJ    

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Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: disease ataxia telangiectasia, encodes a key protein kinase that controls the cellular response to double-strandedbreaks.our understanding of the mechanism of activation of ATM and its signaling pathways, explore whether DNAdouble-strand breaks are the sole activators of ATM and ATM-dependent signaling pathways, and address

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA doublestranded breaks during SHM/CSR.Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repairedregulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 133-139 doi: 10.1007/s11705-018-1737-4

Abstract: In , the global transcriptional regulatory factor CodY can interact with the promoter DNA to regulateIn order to study the mechanism of interaction between CodY and its target DNA, molecular docking andARG218, SER219, ASN223, LYS242 and GLY243, among which SER186, ARG218 and LYS242 play a vital role in DNA

Keywords： CodY     DNA     molecular docking     molecular dynamics    

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Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 261-274 doi: 10.1007/s11684-015-0406-y

Abstract: Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancerIn this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicinewere summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylationFurthermore, prospective applications of DNA methylation to environmental pollution detection and cancer

Keywords： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

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After Artificial Intelligence Breaks Longstanding Matrix Multiplication Records, Humans Quickly Do Better

Dana Mackenzie

Engineering 2023, Volume 28, Issue 9,   Pages 1-3 doi: 10.1016/j.eng.2023.07.002

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Research on an intelligent device for releasing main cable strand of suspension bridge in horizontal

Shen Wang,Yu Jianqun,Gu Qinghua,Mao Youda

Strategic Study of CAE 2010, Volume 12, Issue 7,   Pages 4-7

Abstract: It is based on horizontal retractable technology and used for releasing main cable strand of suspensionThe release quality of main cable strand was greatly improved after the adoption of the device.

Keywords： suspension bridge     main cable strand     intelligent     cable releasing device    

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Single-Molecule Methods for Characterizing Different DNA Higher-Order Structures Review

Yonglin Liu, Tianyuan Bian, Yan Liu, Zhimin Li, Yufeng Pei, Jie Song

Engineering 2023, Volume 24, Issue 5,   Pages 277-292 doi: 10.1016/j.eng.2022.10.009

Abstract: Different DNA structures are related to their biological and chemical functions.However, the bulk assay ignores the heterogeneity of DNA structures in solution.methods, and discuss how these methods can be conducive to measuring the molecular properties of single-/double-strandedDNA (ss/dsDNA), DNA higher-order structures, and DNA nanostructures.methods to understand the biophysical properties of DNA and other bio-matter and soft matter.

Keywords： Single-molecule methods     DNA structure     Mechanical properties     Conformational transitions    

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A DNA Computing Model for the Graph Vertex Coloring Problem Based on a Probe Graph Article

Jin Xu, Xiaoli Qiang, Kai Zhang, Cheng Zhang, Jing Yang

Engineering 2018, Volume 4, Issue 1,   Pages 61-77 doi: 10.1016/j.eng.2018.02.011

Abstract:

The biggest bottleneck in DNA computing is exponential explosion, in which the DNA molecules usedTo overcome this bottleneck and improve the processing speed, we propose a DNA computing model to solveIn this article, a 3-colorable graph with 61 vertices is used to illustrate the capability of the DNAAll these tiny strands are operated by DNA self-assembly and parallel PCR.the largest among both the electronic and non-electronic computers that have been developed since the DNA

Keywords： DNA computing     Graph vertex coloring problem     Polymerase chain reaction    

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Title Author Date Type Operation

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Journal Article

Mechanisms and impacts of chromosomal translocations in cancers

Jing H. Wang

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Microbial community structure in different wastewater treatment processes characterized by single-strand

ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan

Journal Article

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Journal Article

Secondary transfer length and residual prestress of fractured strand in post-tensioned concrete beams

Lizhao DAI; Wengang XU; Lei WANG; Shanchang YI; Wen CHEN

Journal Article

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Journal Article

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Journal Article

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Journal Article

After Artificial Intelligence Breaks Longstanding Matrix Multiplication Records, Humans Quickly Do Better

Dana Mackenzie

Journal Article

Research on an intelligent device for releasing main cable strand of suspension bridge in horizontal

Shen Wang,Yu Jianqun,Gu Qinghua,Mao Youda

Journal Article

Single-Molecule Methods for Characterizing Different DNA Higher-Order Structures

Yonglin Liu, Tianyuan Bian, Yan Liu, Zhimin Li, Yufeng Pei, Jie Song

Journal Article

A DNA Computing Model for the Graph Vertex Coloring Problem Based on a Probe Graph

Jin Xu, Xiaoli Qiang, Kai Zhang, Cheng Zhang, Jing Yang

Journal Article